February 16

Anaplasmosis: Maine’s other tick-borne disease

Few people have heard of the disease, which infects white blood cells and can sometimes be fatal, but cases in Maine have increased tenfold over the past decade.

By Matt Hongoltz-Hetling mhhetling@centralmaine.com
Staff Writer

The patient, who had cancer, had come down with some flu-like symptoms.

click image to enlarge

Preventing tick-borne diseases

The Centers for Disease Control recommends these steps to prevent anaplasmosis and other tick-borne diseases:

• Avoid wooded and bushy areas with high grass and leaf litter.

• Walk in the center of trails.

• Use repellents that contain 20 to 30 percent DEET (N, N-diethyl-m-toluamide) on exposed skin and clothing for protection that lasts up to several hours. Always follow product instructions. Parents should apply this product to their children, avoiding hands, eyes and mouth.

• Use products that contain permethrin on clothing. Treat clothing and gear, such as boots, pants, socks and tents. It remains protective through several washings. Pre-treated clothing is available and remains protective for up to 70 washings.

• Other repellents registered by the Environmental Protection Agency may be found on the EPA’s website.

• Bathe or shower as soon as possible after coming indoors (preferably within two hours) to wash off and more easily find ticks that are crawling on you.

• Conduct a full-body tick check using a hand-held or full-length mirror to view all parts of your body upon return from tick-infested areas. Parents should check their children for ticks under the arms, in and around the ears, inside the navel, behind the knees, between the legs, around the waist and especially in their hair.

• Examine gear and pets. Ticks can ride into the home on clothing and pets, then attach to a person later, so carefully examine pets, coats and day packs.

• Tumble clothes in a dryer on high heat for an hour to kill remaining ticks. (Some research suggests that shorter drying times also might be effective, particularly if the clothing is not wet.)

Reprinted from the Centers for Disease Control and Prevention National Center for Emerging and Zoonotic Infectious Diseases

It was 2008 and Tim Borelli, now a physician who specializes in infectious diseases at MaineGeneral Health Center in Augusta, was in his fellowship at the time.

“She had an illness,” he said. “It was kind of nonspecific.”

The patient’s symptoms ordinarily wouldn’t be cause for alarm, but because the woman was weakened by cancer, Borelli took them seriously.

“We tested her for all kinds of things,” he said. “We look for all possible causes. We check their lungs to make sure they don’t have pneumonia. We do physical exams. Do they have any rashes?”

Tests of her urine showed nothing. Her X-ray was clear. She had no skin infections or stomach problems.

“Then you have to start thinking about different possibilities, such as viral or tick-borne diseases,” Borelli said. “It was in a summer month. Tick-borne diseases are always things we need to consider. And we learned she had had some tick exposure.”

Some of the blood work showed that the woman’s blood didn’t have enough white blood cells in it. Tests also revealed a high level of liver enzymes in the blood, most commonly seen when the liver is damaged or inflamed.

Taken together, the two things pointed to anaplasmosis.

A tick bite usually spurs thoughts of Lyme disease, but a recent rise in anaplasmosis has caught the attention of epidemiologists in the state.

Many people shrug off the effects of anaplasmosis — symptoms can include fever, chills, fatigue, a headache or muscle pain — but in rare cases, especially for those with compromised immune systems, it can kill.

The diagnosis is confirmed most often with a serology test, which tests the blood for very specific antigens — in this case, antigens that the body produces only when anaplasmosis is present.

The woman’s diagnosis wouldn’t have been a problem for the majority of people. Most healthy people don’t even require treatment. A two-week course of doxycycline, the same antibiotic that is used to treat Lyme disease, usually kills the bacteria for those who do need treatment.

But Borelli’s patient’s system was already so weak that it was the final blow.

“She did succumb to that illness,” Borelli said. “That was a sad case.”

The anaplasmosis wasn’t considered the cause of death, he said, but it was a contributing factor.

“Your body’s already being attacked by that cancer,” he said. “The chemo squashes it some more. Then you get an infection that lowers it even further. Then you’re trying to fight that infection with a weakened immune system. That stress, they can’t overcome it sometimes.”

Anyone whose spleen has been removed, who has had a bone marrow transplant or undergone chemotherapy and then gets anaplasmosis is at risk, Borelli said.

About one in 200 people who are diagnosed with the disease die as a result of it, according to the Centers for Disease Control.


About a year after Borelli lost a patient to anaplasmosis, David Letterman, host of “The Late Show” on CBS, told millions of viewers in late July 2009 that he was sick, but he didn’t tell them what he was suffering from, touching off widespread speculation about what it could be.

For a few days in a row, he took his temperature on air, which was more than 100 degrees one night and which topped out at 102.5. He joked that the thermometer reading meant someone won $100 in a pool among the show’s staffers.

That Thursday, he told the audience that he was recovering from anaplasmosis, which he said he probably contracted from a tick while spending the night in a treehouse with his son. He said it left him feeling worse than he had in the aftermath of heart bypass surgery.

(Continued on page 2)

Were you interviewed for this story? If so, please fill out our accuracy form

Send question/comment to the editors

Further Discussion

Here at OnlineSentinel.com we value our readers and are committed to growing our community by encouraging you to add to the discussion. To ensure conscientious dialogue we have implemented a strict no-bullying policy. To participate, you must follow our Terms of Use.

Questions about the article? Add them below and we’ll try to answer them or do a follow-up post as soon as we can. Technical problems? Email them to us with an exact description of the problem. Make sure to include:
  • Type of computer or mobile device your are using
  • Exact operating system and browser you are viewing the site on (TIP: You can easily determine your operating system here.)